Table 4.
ABCB1 c.1236C>T polymorphism and relationships with the area under the artesunate and dihydroartemisinin concentration-time curve (AUC0–12hours)
| Drug | AUC0–12 hours (ng/mL) | ||
|---|---|---|---|
| CC | CT | TT | |
| Artesunate | 999.3 (744.0–1,337.5) [16] | 942.0 (859.0–1,123.0) [29] | 1,067.5 (779.5–1,313.5) [18] |
| Dihydroartemisinin | 2,111.5 (1,925.5–2,261.0) [16] | 2,089.0 (1,875.5–2,370.0) [29] | 1,825.5 (1,414.5–2,560.0) [18] |
CC = wild-type genotype; CT = heterozygous mutation genotype; TT = homozygous mutation genotype. Data are presented as median (95% confidence interval) [number of cases/total cases].