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. 2021 Jun 4;22(Suppl 3):405. doi: 10.1186/s12864-021-07717-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — A brief summary of KLF4, LTR and KRAB-ZFP/TRIM28 regulatory systems in iPSCs, NESCs and ESCs of different vertebrates. Arrows from TFs to LTRs mean direct regulatory relations. Dashed arrow from KLF4 to LTRs of MacERV3 means predicted regulatory relations based on motif analysis with MEME and correlation coefficient between expression levels of KLF4 and these LTRs. “?”: The KRAB-ZFP concordant with TRIM28 in human and mouse iPSC generation and the recruitment of TRIM28 to LTRs of MacERV3 by an unknown KRAB for monkey are still to be verified