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. 2020 Jan 29;223(11):1855–1864. doi: 10.1093/infdis/jiaa016

Figure 2.

Figure 2.

Mean lung colony-forming unit (CFU) counts (±standard deviation) in BALB/c mice after 28 days of treatment with linezolid (LZD) alone or in combination with pretomanid (Pa) in dose-fractionation studies. (A) Linezolid alone in acute infection model. (B) Linezolid in combination with Pa 12.5 mg/kg in acute infection model. (C) Linezolid alone in chronic infection model. (D) Linezolid in combination with Pa 50 mg/kg in acute infection model. Four total weekly LZD doses (0, 100, 300, and 1000 mg/kg per week) were fractionated into 4 dosing schedules: 3 doses/week, 5 doses/week, either 7 or 10 doses/week, and 14 doses/week. The isoniazid (INH), rifampin (RIF), and LZD controls received commonly used doses of 10, 10, and 100 mg/kg per day, respectively, 5 doses/week. Thick horizontal lines indicate the mean CFU count at treatment initiation. Statistical significance determined using one-way analysis of variance with Tukey’s posttest to adjust for multiple comparisons within each dose level: *, P < .05; **, P < .01; ***, P < .001.