Table 1.
Population PK Parameter Estimates
| Model Parameter Estimates | |
|---|---|
| Parameter (Units) | Estimate (RSE, %) |
| VMAX (mg/h per kg) | 3.26 (18) |
| CLin (L/h per kg) | 0.0649 (16) |
| VC (L/kg) | 0.268 (17) |
| ka (h−1) | 7.32 (4) |
| KM (mg/L) | 26.4 FIX |
| Q (L/h per kg) | 0.504 (20) |
| VP (L/kg) | 0.402 (14) |
| F10 mg/kg | 0.184 (5) |
| F30 mg/kg | 0.233 (9) |
| F100 mg/kg | 1 FIX |
| F335 mg/kg | 1 FIX |
| Proportional variability | 0.796 (8) |
Abbreviations: CLin, intrinsic clearance; F, bioavailability; ka, absorption rate constant; KM, Michaelis-Menten constant; PK, pharmacokinetic; Q, blood flow rate; RSE, relative standard error; VC, total body volume of distribution; VMAX, maximum rate of metabolism; VP, plasma volume of distribution.