Table 1.
Median values (ranges) of CTV and PTV coverage measures at baseline and after re-optimization, and two-sided significances of changes in distributions of these measures following re-optimization
| Coverage measure (IDEAL-CRT limit) | At baseline | After MDHeart reduction | After VHeart-50-Gy reduction | After VLAwall-63-Gy reduction |
|---|---|---|---|---|
| DPTV-90%* (≥ 95% prescribed dose) | 98.6% (96.7, 99.0%) |
97.9% (95.7, 98.9%) p = 6 × 10–4 |
98.0% (96.3, 98.9%) p = 2 × 10–4 |
98.4% (95.3, 99.0%) p = 0.31 |
| DPTV-98% (≥ 90% prescribed dose) | 96.7% (92.4, 97.9%) |
95.0% (90.7, 97.3%) p = 4 × 10–4 |
95.1% (91.5, 97.5%) p = 2 × 10–4 |
96.4% (90.4, 97.7%) p = 0.09 |
| DCTV-99% (≥ 95% prescribed dose) | 98.0% (96.5, 98.6%) |
97.6% (95.7, 98.4%) p = 7 × 10–3 |
97.7% (96.1, 98.4%) p = 8 × 10–3 |
97.9% (95.6, 98.6%) p = 0.27 |
| DPTV-99.5% (non-protocol measure) | 95.2% (86.5, 96.9%) |
91.9% (86.7, 96.4%) p = 1 × 10–3 |
92.5% (86.0, 96.4%) p = 3 × 10–4 |
94.6% (86.9, 96.6%) p = 0.09 |
*DStructure-X% denotes the minimum percentage of the prescribed dose covering the most highly irradiated X% of a structure