Table 2.
Median values (ranges) of measures of irradiation of both lungs excluding iGTV, at baseline and after re-optimization, and two-sided significances of changes in distributions of these measures following re-optimization
| Dose-volume measure | At baseline | After MDHeart reduction | After VHeart-50-Gy reduction | After VLAwall-63-Gy reduction |
|---|---|---|---|---|
| EQD2Lung-mean* | 13.7 Gy (8.0, 16.8 Gy) |
13.9 Gy (7.2, 16.6 Gy) p = 0.03 |
13.7 Gy (7.7, 16.7 Gy) p = 0.07 |
14.1 Gy (8.0, 16.8 Gy) p = 0.86 |
| Mean lung dose | 15.7 Gy (9.4, 19.5 Gy) |
15.8 Gy (8.5, 19.3 Gy) p = 0.03 |
15.7 Gy (9.1, 19.4 Gy) p = 0.06 |
16.0 Gy (9.4, 19.5 Gy) p = 0.89 |
| VLung-10-Gy** | 47.2% (29.0,70.9%) |
46.3% (27.6, 73.9%) p = 5 × 10–3 |
46.5% (29.0, 76.5%) p = 0.16 |
47.5% (29.0, 77.4%) p = 0.88 |
| VLung-20-Gy | 27.2% (15.6, 34.4%) |
28.1% (13.6, 34.8%) p = 0.98 |
26.4% (14.9, 34.5%) p = 0.30 |
26.4% (15.6, 34.9%) p = 0.94 |
| VLung-30-Gy | 17.1% (7.9, 23.7%) |
16.4% (6.7, 24.5%) p = 0.59 |
16.7% (7.7, 23.7%) p = 8 × 10–3 |
16.6% (7.9, 23.7%) p = 0.72 |
| VLung-50-Gy | 7.0% (2.6, 12.2%) |
6.9% (2.2, 14.4%) p = 1.00 |
7.0% (2.4, 12.6%) p = 0.05 |
7.5% (2.6, 12.2%) p = 0.30 |
*Equivalent dose in 2 Gy fractions averaged across both lungs minus iGTV
**The fraction of both lungs minus iGTV receiving ≥ 10 Gy