Fig. 5.

Downregulation of miR-1287-5p reversed the inhibitory effects of circ_0001982 knockdown on progression of BC cells. a–h MDA-MB-231 and MDA-MB-468 cells in normal and hypoxia conditions were transfected with si-NC, or si-circ_0001982, si-circ_0001982 + anti-miR-NC, or si-circ_0001982 + anti-miR-1287-5p, respectively. a, b The expression of miR-1287-5p and the transfection efficiency was evaluated using qRT-PCR. c, d The glucose consumption in the transfected BC cells was detected. e, f The lactic acid production in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment was evaluated. g, h Western blot assay was used to detect the protein level of HK2 in MDA-MB-231 and MDA-MB-468 cells under 48 h of hypoxia treatment. *P < 0.05