Table 2.
Pathway analysis of the differentially expressed genes (P < 0.05)
| Comparison | Major Enriched Pathways | Associated Genes |
|---|---|---|
| HC versus NC↑ | Jak-STAT signaling pathway | Prlr, Pik3r5, Pim1, Cntfr, Csf2rb, Il22ra2, Il10ra |
| TNF signaling pathway | Cx3cl1, Icam1, Pik3r5, Map2k6, Ifi47, Edn1, Il1b, Ccl5, Mapk13, Mmp9 | |
| NF-kappa B signaling pathway | Il1b, Lbp, Icam1, Bcl2a1d, Ccl4 | |
| HC versus NC↓ | Arachidonic acid metabolism | Ptgr1, Ptgis, Cyp4a14, Ptges |
| Insulin signaling pathway | Fasn, Acaca, Pik3r5, Mtor, Fbp1, Ppp1r3c, Srebf1, Hras | |
| HE versus HC↑ | Arachidonic acid metabolism | Cyp1a1, Cyp4a32, Ptges, Cyp4a31, Cyp4a10, Ptgr1, Ptgis, Cyp4a14, Ptgs2 |
| AMPK signaling pathway | Lep, Pfkfb3, Ccnd1, Pfkl, Pik3r5, Pfkp, Scd2, Prkab1, Fasn, Fbp1, Scd3, Gys2, Acaca, Ppp2r5b, Pik3r1, Irs2 | |
| PPAR signaling pathway | Me1, Scd3, Ehhadh, Hmgcs2, Cyp4a32, Cyp4a31, Fabp5, Cyp4a10, Acsl5, Cyp4a14, Acox2, Scd2 | |
| Insulin signaling pathway | Pik3r1, Fasn, Acaca, Pde3a, Prkab1, Fbp1, Pik3r5, Gys2, Hk1, Hk2, Cblc, Irs2 | |
| VEGF signaling pathway | Pik3r5, Pik3r1, Nos3, Mapkapk3, Ptgis, Ptgs2 | |
| HE versus HC↓ | Jak-STAT signaling pathway | Lep, Myc, Ccnd1, Pik3r5, Pik3r1, Cish, Cntfr, Il22ra2, Cblc |
| ErbB signaling pathway | Zfyve28, Cdh13, Cblc, Btc | |
| TGF-beta signaling pathway | Myc, Cdkn2b, Id2, Acvr1c, Skp1a, Bmp8b, Bmpr1b, Tgfbr2 |
Janus kinases/signal transducer and activator of transcription (JAK/STAT); Tumor necrosis factor (TNF); Nuclear factor-kappa B (NF-kappa B); Adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK); Receptor tyrosine-protein kinase erbB isoform b (ErbB); Peroxisome proliferator-activated receptor (PPAR); Vascular endothelial growth factor (VEGF); Transforming growth factor-beta (TGF-beta). n = 3