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. 2021 Jun 4;22:172. doi: 10.1186/s13059-021-02391-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — RNA abundance divides snoRNAs into two classes with distinct tissue distribution. A SnoRNA abundance accurately clusters healthy human tissues. The heatmap indicates the abundance level of the expressed snoRNAs in 21 RNA samples from 7 different human tissues (legend for the abundance class color bar on the left is shown in B). Only snoRNAs with an abundance greater than 1 TPM in at least one sample are considered. The color scale for the abundance is shown on the right. B SnoRNAs are divided into two abundance classes. The number of snoRNAs in the uniformly expressed and tissue-enriched classes is shown in the form of a pie chart. C Most tissue-enriched snoRNAs are less abundant than their uniformly expressed counterparts. The bar chart indicates the number of both tissue-enriched and uniformly expressed snoRNAs in the different ranges of average RNA abundance across tissues. D Most tissue-enriched snoRNAs are expressed in the brain. The number of uniformly expressed and tissue-enriched snoRNAs with an abundance of at least 1 TPM in the examined tissues is displayed on the left, while the total RNA abundance of each class of snoRNAs detected in the different tissues is shown on the right.