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. 2021 Jun 3;22:408. doi: 10.1186/s12864-021-07693-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 13 — Meta-analysis of genes reflective for developmental environment and differential expressed between ICM and TE cells. a Venn diagram depicting genes differentially expressed in CVT vs. CVO as well as in ICM vs. TE cells of in vivo derived embryos. The arrows on the left hand indicate expression trend of genes in CVT compared to CVO blastocysts whereas the arrows on the right side indicate expression trend of these genes in ICM relative to TE cells of in vivo derived embryos. b Venn diagram depicting genes differentially expressed in CVT vs. CVO as well as in ICM vs. TE cells of in vitro derived embryos. The arrows on the left hand indicate expression trend of genes in CVT compared to CVO blastocysts whereas the arrows on the right side indicate expression trend of these genes in ICM relative to TE cells of in vitro derived embryos. c Molecular pathways enriched by genes differentially expressed both in CVT vs. CVO blastocysts as well as in ICM vs. TE cells