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. 2021 Jun 3;14:145. doi: 10.1186/s12920-021-00991-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Comparison of the expression of genes related to different immune regulators in GSE100927. ns: p > 0.05, *p < = 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. 80 genes were detected in GSE100927. A–E were a set of comparisons between atheromatous plaques and healthy control: A box plot comparing the expression of human leukocyte antigen (HLA)-related genes, B immune checkpoint-related genes, C IFN-γ pathway marker genes, D m6A methylation regulator-related genes, E circadian rhythm-related genes. F–J were a set of comparisons between atheromatous plaques in the ImmuneScoreH cluster with that in atheromatous plaques in the ImmuneScoreL cluster: F Box plot comparing the expression of HLA-related genes, G immune checkpoint-related genes, H IFN-γ pathway marker genes, I m6A methylation regulator-related genes, J circadian rhythm-related genes. K Summarized the consistent results between the two sets of comparisons (atheromatous plaques vs. healthy controls/ImmunceScoreH cluster vs. ImmunceScoreL cluster)