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. 2021 May 5;41(18):4131–4140. doi: 10.1523/JNEUROSCI.2521-20.2021

Figure 2.

Figure 2.

The antidepressant effects of systemic injection of (R,S)-ketamine in CRS rats following LHb lesions. A, Schematic illustration of experimental protocol. B, A representative Nissl-stained brain section from the lesion group. C, Effect of intraperitoneal injection of (R,S)-ketamine on the LMA. n.s., Not significant. n = 6–8. D, Effect of intraperitoneal injection of (R,S)-ketamine on the immobile time in the FST. *p < 0.05, **p < 0.01; n = 6–8. E, Effect of intraperitoneal injection of (R,S)-ketamine on the latency to immobility onset of FST. *p < 0.05, **p < 0.01; n = 6–8. F, Effect of intraperitoneal injection of (R,S)-ketamine on the SPT. *p < 0.05, **p < 0.01; n = 6–9. Seven rats were removed from the analysis for incorrect LHb lesions (C–F). LMA, Locomotion activity.