Effect of systemic injection of (R,S)-ketamine on mEPSC of LHb neurons and expression of GluR1. A, Schematic illustration of experimental protocol. B, Recording sites of each tetrode and example mEPSC traces of LHb neurons. C, Effect of systemic administration of (R,S)-ketamine on the cumulative distribution of mEPSC amplitude of LHb neurons. ***p < 0.001; n = 12–15. D, Effect of systemic administration of (R,S)-ketamine on the cumulative distribution of mEPSC interevents interval and average frequency of LHb neurons. *p < 0.05; n = 12–15. E, Effect of systemic administration of (R,S)-ketamine on the expression of GluR1 in LHb. **p < 0.01; n = 6–8.