Table 1.

Summary of qPCR results in cross-sectional and longitudinal cohorts for cf-nDNA and cf-mtDNA

Cohort	Gene marker	cf-nDNA (ng/mL)			Gene marker	cf-mtDNA (fold change)
		HC	SCD-Baseline	SCD-Crisis		HC	SCD-Baseline	SCD-Crisis
Cross-sectional*	GAPDH	6.85	9.65	22.01	MT-ND1/GAPDH	7.8	153.3	63.4
					MT-ND1/TERT	5.4	44.1	40
	TERT	11.05	16.2	38.38	MT-ND6/GAPDH	19.1	142.3	70.5
					MT-ND6/TERT	9.7	44.4	46.4
Paired (n = 18)	GAPDH		6.14	23.9	MT-ND1/GAPDH		65.7	63
					MT-ND1/TERT		44.5	41.6
	TERT		13.56	41.65	MT-ND6/GAPDH		81.5	76.8
					MT-ND6/TERT		54.8	50.9

^*HC, n = 13; SCD-Baseline, n = 72; SCD-Crisis, n = 20.