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Sites of cleavage by APC in fV and fVa. Residues R306 (A,C) and R506 (B,D) are 75% buried in fV (A-B) but 60% exposed in fVa (C-D). Mesh refers to residues 304 to 308 (A,C), 504 to 508 (B), and 504 to 507 (D) and was contoured at 1 σ.