Fig. 1.

Tumor models used for experiments: (a) Pigmented melanoma (B16-F10 cell line) grown in the flank of seven-week-old nude mouse; (b) NRG mouse with installed dorsal skin window chamber (DSWC) bearing a pancreas adenocarcinoma (BxPC-3 cell line); (c) The same animal in (b) shown en-face. Several millimeters thick tumor is labeled with red arrow; (d) Melanoma bearing mouse under the OCT imaging probe on a heating pad. Scanning OCT light is highlighted with the red LED light coupled into the sample arm optical fiber. (e) Pancreatic adenocarcinoma bearing mouse under the OCT imaging probe secured with 3D printed animal restrainer; (f) Anesthetized NRG mouse inside the microirradiator under the custom-built 12×6 mm² semicircular collimator; (g) and (h) Gafchromic film on the top of the window chamber glass before and after the treatment confirming the X-ray treated area.