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. Author manuscript; available in PMC: 2021 Jun 4.
Published in final edited form as: Nat Struct Mol Biol. 2021 Feb 25;28(3):258–267. doi: 10.1038/s41594-020-00554-6

Extended Data Fig. 8 |. Cryo-EM structure of the NTS-NTSR1-Gi complex in lipid nanodiscs and the interaction with lipid.

Extended Data Fig. 8 |

a, Three views of the cryo-EM density map of the NTS-NTSR1-Gi-cND complex in the canonical state. b, Three views of the cryo-EM density map of the NTS-NTSR1-Gi-cND complex in the noncanonical state. The maps in panels (a) and (b) are low-pass filtered to 5 Å and colored by subunit. c, Two views of NTS-NTSR1 surrounded by nanodisc density. The transmembrane helices are shown in cylinder representation using the rainbow coloring scheme. ICL2 and helix H8 are partially submerged in lipid.