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. 2021 May 21;12:670971. doi: 10.3389/fimmu.2021.670971

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Copyright © 2021 Deng, Yin, Zhang, Zhou and Hou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Function analysis and validation of PLA2G7. (A) The relationship between PLA2G7 and the clinical characteristics (age, BMI, FVC%predicted and FEV1/FVC) of COPD patients; (B) GSEA results showed that several immune-related pathways were significantly associated with PLA2G7; (C) Relationship between PLA2G7 expression and immune cell infiltration level; red: statistically significant (P < 0.05); (D) PLA2G7 expression was increased in blood of COPD patients based on GSE42057 (left) and GSE56766 (right); (E) PLA2G7 expression were up-regulated in alveolar macrophages of COPD samples based on GSE130928 (left) and GSE13896 (right).