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TNS1 plays a role in fibronectin assembly in the ECM and ECM scavenging (GREEN BOX), Inflammation via TGFB1 increases the expression of TNS1 leading to cell differentiation into myofibroblasts and upregulates TNS1 in myofibroblasts to increase ECM component production, such as collagen and fibronectin which leads to fibrosis. (RED BOX)
