Name	NC/NA	1	2	3	4	5	All grades
Anemia	67%	0%	11%	22%	0%	0%	33%
Leukocytes (total WBC)	78%	0%	22%	0%	0%	0%	22%
Lymphopenia	89%	0%	11%	0%	0%	0%	11%
Neutrophil count decreased	78%	0%	22%	0%	0%	0%	22%
Platelets	56%	0%	0%	22%	22%	0%	44%
Anorexia	89%	0%	11%	0%	0%	0%	11%
Arthralgia	78%	0%	22%	0%	0%	0%	22%
Cough	78%	0%	22%	0%	0%	0%	22%
Dizziness	89%	0%	11%	0%	0%	0%	11%
Dysgeusia	89%	0%	11%	0%	0%	0%	11%
Dyspepsia	89%	0%	11%	0%	0%	0%	11%
Dyspnea (shortness of breath)	67%	0%	22%	11%	0%	0%	33%
Alanine aminotransferase increased	89%	0%	11%	0%	0%	0%	11%
Aspartate aminotransferase increased	89%	0%	0%	11%	0%	0%	11%
Blood bilirubin increased	89%	0%	11%	0%	0%	0%	11%
Fatigue (asthenia, lethargy, malaise)	78%	0%	22%	0%	0%	0%	22%
Hot flashes/flushes	89%	0%	11%	0%	0%	0%	11%
Hypertension	33%	0%	67%	0%	0%	0%	67%
Hypotension	89%	0%	11%	0%	0%	0%	11%
Hypoxia	89%	0%	0%	11%	0%	0%	11%
Heart failure	89%	0%	11%	0%	0%	0%	11%
Lip infection	89%	0%	11%	0%	0%	0%	11%
Nausea	78%	0%	11%	11%	0%	0%	22%
Pulmonary hypertension	89%	0%	0%	11%	0%	0%	11%
Rash	78%	0%	11%	11%	0%	0%	22%
Right ventricular dysfunction	89%	0%	11%	0%	0%	0%	11%
Insomnia	89%	0%	11%	0%	0%	0%	11%

Cycle 1 toxicities in any dose level.

Abbreviations: NC/NA, no change from baseline/no adverse events; WBC, white blood cell.