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| Dose level | Dose of drug: Ixazomib | Dose of drug: fulvestrant | Number enrolled | Cmax (ng/mL) mean ± SD | Tmax(h) (min ‐ max) | AUC 0–12 (ng*h/mL) mean ± SD | T ½(h) mean ± SD |
|---|---|---|---|---|---|---|---|
| A | 2.3 mg | 500 mg | 3 | 50.5 ± 25.8 | 0.5–2 | 1978.8 ± 461.6 | 160.2 ± 48.0 |
| B | 3 mg | 500 mg | 3 | 61.5 ± 34.3 | 1–2 | 2,507.1 ± 890.4 | 101.3 ± 26.2 |
| C | 4 mg | 500 mg | 3 | 149.3 ± 25.0 | 1–1.5 | 5,459.4 ± 20.6 | 75.5 ± 23.9 |
Abbreviations: AUC, area under the curve; Cmax, maximal concentration; Tmax, time of maximal concentration.
