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(A): The computed tomography (CT) scan of the patient before apatinib showed the uncontrolled primary tumor (white arrow). (B): The patient with tracheal esophageal fistula, 25 days after treatment. (C): The CT scan of the patient before apatinib showed the uncontrolled primary tumor (white arrow). (D): The patient with mediastinoesophageal fistula, 30 days after treatment.
