Figure 4.

IL15 infusions increase cytotoxic activities in both NK-cell subsets. A, Intracellular stains of gated NK subsets indicate decreases of cytotoxic molecules in CD56^dim NK cells, whereas the amounts of granzymes A, B, and perforin increased in CD56^bright NK cells after IL15 infusions. B, IL15 infusions augmented cytolytic activities for both sorted NK-cell subsets against three different target lines. Analyses were done once on each of 5 patients. Graphs depict mean ± SD. *, P < 0.05; **, P < 0.01; and ***, P < 0.001.