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. 2021 May 3;12:654225. doi: 10.3389/fimmu.2021.654225

Figure 6.

Figure 6

Ly49H signaling is also involved in the regulation of nutrient transporters expression on NK cells upon MCMV infection. (A) NK cells were enriched from the spleen of naive C57BL/6 mice and co-cultured with either BAF3 or BAF3-m157 cells for 18 hours. The mean fluorescence intensity (MFI) of CD71 and CD98 expression on NK cells was measured by flow cytometer. Data are from one experiment representative of 2 independent experiments with at least two replicates per group. (B) C57BL/6 mice were either left untreated or infected with 15,000 PFU MCMV intraperitoneally and analyzed on the indicated day. Representative plots depict the MFI of CD71 and CD98 expression on NK cells in the spleen of naive (D0) or MCMV-infected mice at day 3 post-infection (D3). (C) Representative plots depict the MFI of NAO expression on NK cells in the spleens of naive (D0) or MCMV-infected mice at D3 post-infection. Data are from one experiment representative of 2 independent experiments with three to five mice per group. The MFI expression is presented in percentage relative to the MFI of control as 100. Data represent mean + SD. NS, non-significant, *p < 0.05; **p < 0.01.