Fig. 2.

A model of the integration of the activation of mTOR leading to the subsequent expression of the transcription factor NF-kb (IL-1b and IL-6) responsible of Inflammation and Cytokine Storm. The nutritional-hormonal pathway that begins with the activation of a transmembrane ligand receptor (Pathway 1 in orange arrows) and the processed viral-RNA pathway that begins at the lysosomal membrane with TLR7-9 activation (Pathway 2 in green arrows) both leading to mTOR activation and the downstream cascade in grey arrows