Table 1.

Representative red flags for ATTR amyloidosis

For neurologists

Carpal tunnel syndrome (bilateral)

Sensorimotor polyneuropathy and at least one of the following findingsa

Positive family history

Cardiac symptoms

Autonomic symptoms

Diarrhea/constipation

Orthostatic intolerance/syncope

Dysuria

Unexplained weight loss

Ocular symptoms (vitreous opacities)

For cardiologists

Heart failure with preserved ejection fraction and at least one of the following findings

Polyneuropathya

Positive family historya

Carpal tunnel syndrome

Characteristic electrophysiology and imaging findingsb

Electrocardiogram

Low voltage in the limb leads

Abnormal Q waves (pseudoinfarct pattern)

Echocardiography

Thickened left ventricular wall and interventricular septum

Hyperrefractile myocardial echoes (granular sparkling appearance)

^aOnly applied to ATTRv amyloidosis

^bOnly conventional findings are shown here