Figure 6.

(A) Schematic summary of in situ spraying of aCD47@CaCO₃ nanoparticle-containing fibrin gel in the postsurgery tumor bed. (B) Transmission electron microscopy (TEM) image of aCD47@CaCO₃ nanoparticles (scale bar 100 nm). (C) Cryo-SEM images of fibrin gel loaded with aCD47@CaCO₃ nanoparticles (scale bar 1 μm). (D) Cumulative release profiles of aCD47 from fibrin at different pH. Data are presented as mean ± SEM. (E) In vivo retention of Cy5.5-labeled aCD47 administered in different formulations after 6 days. (F) Average tumor growth curves in different groups. (G) Schematic illustration of aCD47@CaCO₃@fibrin therapy in a mouse model of incomplete tumor resection and distant tumor. (H) Growth curves for left and right tumors in untreated and treated mice. Data are presented as mean ± SEM, *P < 0.05. Reprinted and modified with permission from ref 37. Copyright 2019 Springer Nature Limited.