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. Author manuscript; available in PMC: 2021 Jun 4.
Published in final edited form as: Acc Chem Res. 2020 Oct 19;53(11):2521–2533. doi: 10.1021/acs.accounts.0c00339

Figure 8.

Figure 8.

(A) Schematic summary of the production of PD-1-expressing platelets. (B) Evolution process of PD-1-expressing proplatelets from MKs (scale bar 10 μm). (C) Average tumor volumes of mice with different treatments. Data are shown as the mean ± SEM. (D) Immunofluorescence of tumor sections verifying the infiltration of CD4+ and CD8+ T cells (scale bar 100 μm). (E) Average tumor volumes of mice with different treatment groups as indicated. Data are shown as the mean ± SEM. (F) Quantification of FoxP3 expression in CD4+ T cells within the tumors analyzed by flow cytometry (gated on CD4+ T cells). *P < 0.05; **P < 0.01; ***P < 0.005. Reprinted and modified with permission from ref 51. Copyright 2018 American Chemical Society.