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. Author manuscript; available in PMC: 2021 Jun 4.
Published in final edited form as: Acc Chem Res. 2020 Oct 19;53(11):2521–2533. doi: 10.1021/acs.accounts.0c00339

Figure 9.

Figure 9.

(A) Schematic summary of HSC–platelet dual cell assembly assisted aPD1 delivery. (B) Confocal microscopy image of S-P-aPD1 conjugates. (C) Fluorescence images of bone tissues from mice treated with saline (1), Cy5.5-labeled free aPD1 (2), P-aPD1 (3), S-aPD1 (4), S + P-aPD1 (5), and S-P-aPD1 (6). (D) Survival curves for mice with different groups indicated. (E, F) Quantitative analysis of the percentage of CD3+ and CD8+ T cells. Data are presented as mean ± SD. **P < 0.01; ***P < 0.005. (G) Bioluminescence of mice rechallenged with C1498 cells after 3 weeks. Reprinted and modified with permission from ref 2. Copyright 2018 Springer Nature Limited.