Extended Data Fig. 9. LZTR1 minor intron retention is pervasive in cancers.

(a) Degree of major (U2-type) intron retention across normal (N) and tumor (T) samples in cancers from TCGA. Each point corresponds to a single U2-type intron and indicates the percentage of all tumor samples in which retention of that intron exceeds the maximum corresponding retention of that intron observed in normal samples. Red dot indicates the U12-type intron of LZTR1 for comparison. (b) Each point illustrates the frequency of retention of a single intron of LZTR1 (see inset for key) across all TCGA cohorts with matched normal samples. Values along the x axes represents the mean difference in intron retention in tumor versus normal samples within a cancer type, while the y axes represent the fraction of tumor samples with intron retention that exceeds that of the normal sample with the most intron retention within a cancer type. Points represent the mean value computed across all cancer types, while whiskers represent the interquartile range across cancer types. (c) As (b), but whiskers represent the entire range.