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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Apr 22;1867(8):166153. doi: 10.1016/j.bbadis.2021.166153

Fig. 5.

Fig. 5.

Regulation of FXR target genes in vivo by single dose administration of secondary isoBAs and GW4064. (A) Regulation of Fgf15 and Ibabp pre-mRNA and mRNA by GW4046, isoDCA+GW4064 and isoUDCA+GW4064. (B) Repression of bile acids synthesis genes (Cyp7a1 and Cyp8b1) in livers of mice treated with isoBAs and GW4064 as well as (C) serum cholesterol and triglyceride levels. Administration of isoBAs (isoUDCA and isoDCA) followed by GW4064 with 1 h time-delay for a total of 6 h. Mice are gavaged with olive oil (vehicle), GW4064 (30 mg/kg BW), and isoBAs (60 mg/kg BW). Genes were analyzed 6 h after gavage; n = 3–4, values represent the mean ± SEM. *p < 0.05; #p < 0.01.