Table 1.

Binding affinity (kcal/mol) of anti-severe acute respiratory syndrome-coronavirus-2 comparator on the targeted protein RNA-dependent RNA polymerase, spike glycoprotein, and 3C-like protease

Compounds	Receptor
	RdRp	Spike	3CLpro
5,6,7-trihydroxy- 2-phenyl-4H-chromen - 4-one	ND	ND	−7.8
Remdesivir	−8.2	−6.6	−6.7
Hydroxychloroquine	−6.7	−5.7	−6.5
Chloroquine	−5.8	−5.9	−6.0

ND: Not determined, 3CL^pro: 3C-like protease, RdRp: RNA-dependent RNA polymerase