Table 2.
Gas Exchange, Respiratory Mechanics and Ventilatory Parameters of 34 Patients With COVID-19-induced ARDS According to the Presence or Absence of Pulmonary Fibrotic-like Changes and Its Extensive Form.
| COVID-19-induced ARDS With Fibrotic-Like Changes n = 24 |
COVID-19-induced ARDS Without Fibrotic-Like Changes n = 10 |
COVID-19-induced ARDS With Extensive Fibrotic-like Changes n = 12 |
P-value Fibrotic-like Changes vs. None |
P-value Extensive Fibrotic-like Changes vs. None |
|
|---|---|---|---|---|---|
| Gas exchange, respiratory mechanics and ventilatory parameters upon ARDS diagnosis, median (Q1; Q3) | |||||
| PaO2/FiO2 | 177 (124; 232) | 170 (111; 191) | 183 (115; 237) | .34 | .42 |
| Ventilatory ratio | 1.87 (1.68; 2.15) | 1.81 (1.28; 2.19) | 1.91 (1.70; 2.11) | .54 | .79 |
| Tidal volume, mL/IBW | 7.13 (6.39; 7.59) | 6.42 (5.71; 7.04) | 6.84 (6.34; 7.65) | .042 | .14 |
| PEEP, cmH2O | 13 (12; 14) | 12 (10; 13) | 13 (12; 14) | .16 | .28 |
| Positive end-inspiratory pressure, cmH2O | 24 (21; 26) | 23 (21;25) | 25 (24; 27) | .19 | .044 |
| Driving pressure, cmH2O | 11 (9; 13) | 11 (10; 13) | 12 (11; 15) | .69 | .25 |
| Mechanical power, J/min | 22 (18; 28) | 22 (19; 33) | 21 (17; 24) | .66 | .36 |
| Respiratory system compliance, TV * cmH2O−1 | 40 (30; 53) | 39 (36; 45) | 35 (24; 43) | .67 | .23 |
| Gas exchange, respiratory mechanics and ventilatory parameters on day 3 since ARDS diagnosis, median (Q1; Q3) | |||||
| PaO2/FiO2 | 220 (155; 253) | 200 (157; 222) | 209 (162; 260) | .58 | .79 |
| Ventilatory ratio | 2.03 (1.79; 2.26) | 1.56 (1.37; 1.94) | 1.98 (1.80; 2.39) | .011 | .015 |
| Tidal volume, mL/IBW | 7.50 (6.81; 7.92) | 6.46 (5.71; 6.76) | 7.51 (6.85; 7.82) | .005 | .01 |
| PEEP, cmH2O | 12 (10; 13) | 12 (10;13) | 12 (9; 13) | .82 | .66 |
| Positive end-inspiratory pressure, cmH2O | 23 (22; 26) | 23 (16; 24) | 24 (22; 27) | .11 | .09 |
| Driving pressure, cmH2O | 11 (10; 13) | 10 (6; 11) | 12 (11; 15) | .055 | .059 |
| Mechanical power, J/min | 23.37 (21.1; 29.9) | 26.38 (18.7; 34.1) | 22.12 (16.7; 28.5) | .64 | .46 |
| Respiratory system compliance, TV * cmH2O−1 | 37 (31; 46) | 50 (41; 70) | 36 (27; 46) | .08 | .11 |
Abbreviations: ARDS: acute respiratory distress syndrome; IBW: ideal body weight; mL: milliliters; PEEP: positive end-expiratory pressure; TV: tidal volume.