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. 2021 Jun 4;16(6):e0249174. doi: 10.1371/journal.pone.0249174

Table 3. Cox proportional regression analysis of the correlation of clinical factors and the lncRNA signature risk score with OS in BCa patients.

Variables Univariate analysis P value Multivariate analysis P value
HR (95%CI) HR (95%CI)
Menopause (Indeterminate VS Peri VS Post VS Pre) 1.036 (0.749,1.431) 0.832 0.668 (0.438,1.018) 0.061
Tumor Status (Tumor free VS With tumor) 11.869(6.384,22.065) <0.001 13.974(6.753,28.915) <0.001
Age (<65 VS. ≥65) 1.032 (1.009,1.057) 0.007 1.065 (1.035,1.095) <0.001
Surgical (Lumpectomy VS Modified Radical Mastectomy VS Other VS Simple Mastectomy) 1.091 (0.829,1.437) 0.533 1.150 (0.852,1.553) 0.362
T (T1 vs T2 VS T3 VS T4) 1.365 (0.950,1.961) 0.092 0.814 (0.492,1.347) 0.423
N (N0 vs N1 VS N2 VS N3 VS Nx) 2.053 (1.640,2.737) <0.001 1.390 (0.846,2.283) 0.194
M (M0 VS M1 VS Mx) 3.504 (1.365,8.992) 0.009 0.305 (0.074,1.249) 0.099
Stage (I VS. II VS. III VS IV) 2.297 (1.586,3.327) <0.001 1.223 (0.518,2.889) 0.646
RiskScore (high VS. low) 1.069 (1.041,1.098) <0.001 1.077 (1.047,1.109) <0.001

HR: hazard ratio; CI: confidence interval.