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. 2021 Jun 4;16(6):e0252607. doi: 10.1371/journal.pone.0252607

Fig 1. HSPG core proteins and HS rapidly decline in the pancreatic islets of db/db mice.

Fig 1

(A) Representative images show the distribution of HSPG core proteins and HS in the islets of male db/db mice and wt mice at 4 and/or 6 weeks of age as demonstrated by immunohistochemical staining. (B-E) Bar graphs for each time point show morphometric analysis of the % islet stained for the HSPG core proteins (B) COL18, (C) SDC1, (D) CD44 and HS (E) in pancreases of lean control male mice (wt, db/+; open bars) and db/db mice (shaded bars). Data show mean ± SEM for 3–6 pancreases/age group with n = 21–72 islets examined/group for HSPG core proteins and n = 19–52 islets/group for HS. *p<0.05, **p<0.01 and ***p<0.0001, Mann-Whitney test (HSPGs) and Unpaired t test (HS). Scale bar = 100 μm.