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. 2021 Jun 4;16(6):e0252825. doi: 10.1371/journal.pone.0252825

Table 1. Assessment and measurement of saccades, and OCT imaging of each NPC patient, and the respective means of the control group.

ID Age [years] NPC disability score Peak velocity [°/s] (number of recorded saccades) 30° rightwards clinical score 30° leftwards clinical score 20° upwards clinical score 20° downwards clinical score Compensating corollary Macular OCT Peripapillary OCT
1 26 8 315 (3) 1 244 (1) 1 N.A. (0) 3 N.A. (0) 3 B, H normal normal
2 18 11 218 (2) 0 284 (6) 0 N.A. (0) 2 N.A. (0) 1 B normal N.A.
3 43 11 233 (6) 0 289 (5) 0 66 (3) 3 N.A. (0) 3 B normal normal
4 10 9 123 (4) 0 110 (2) 0 42 (1) 2 N.A. (0) 2 B N.A. N.A.
5 7 5 268 (5) 0 263 (5) 0 N.A. (0) 2 359 (3) 2 B N.A. N.A.
6 17 2 401 (6) 0 456 (7) 0 80 (3) 2 105 (5) 2 E normal normal
7 28 8 318 (4) 0 383 (7) 0 112 (1) 2 53 (1) 2 B normal normal
8 21 12 334 (7) 0 351 (6) 0 184 (1) 2 63 (1) 2 H normal normal
9 14 N.A. 318 (3) 0 263 (3) 1 N.A. (0) 3 N.A. (0) 2 none N.A. N.A.
10 8 6 393 (4) 0 456 (2) 0 401 (4) 0 255 (4) 0 none normal normal
11 18 8 0 0 2 3 none normal normal
12 7 N.A. 0 0 2 3 none N.A. N.A.
13 6 N.A. 1 1 3 3 H N.A. N.A.
14 14 N.A. 0 0 3 1 H N.A. N.A.
15 21 N.A. 0 0 0 1 B N.A. N.A.
16 21 8 1 1 2 3 none N.A. N.A.
17 20 N.A. 0 0 3 2 B N.A. N.A.
18 19 N.A. 0 0 3 3 B N.A. N.A.
Controls 33 (SD 18) N.A. 459 (SD 67) [305–677] 451 (SD 66) [259–645] 404 (SD 74) [224–609] 378 (SD 67) [216–554] N.A. normal normal

B = vertical eye movements were initiated by blinking, H = compensatory or defense head movements in vertical eye movements (either upwards, or downwards, or both), E = compensating horizontal eye movements when vertical eye movements were tested.

Clinical saccade testing: 0 = normal, 1 = slowed slightly, 2 = slowed a lot, 3 = not triggerable, 4 = not assessable.

SD = standard deviation.