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. Author manuscript; available in PMC: 2021 Jun 4.
Published in final edited form as: J Med Primatol. 2020 Aug 17;49(5):284–287. doi: 10.1111/jmp.12485

Figure 1. SIVcpzLB715 infection kinetics during the second generation in hu-HSC mice.

Figure 1.

(A) Experimental scheme for SIVcpzLB715 infection of hu-HSC mice. Neonatal mice are sublethally irradiated and inoculated intrahepatically with CD34+ hematopoietic stem cells. Following SIVcpzLB715 inoculation, PVL were assessed weekly and CD4+ T-cell decline bimonthly. (B) Second generation PVL and CD4+ T-cell decline seen in SIVcpzLB715 infected hu-HSC mice. Statistically significant CD4+ T-cell depletion occurred by the end of the second generation in infected mice relative to the uninfected mice (two-tailed Student’s t-test, *p<0.001).