Fig. 1. Decoding cancer therapy–induced remodeling via machine learning.

Anticancer therapy significantly remodels the tumor microenvironment (TME). The extent of remodeling can be quantified through multiple biomolecular techniques. Applying machine learning and network analysis to clinical data and complex multiomic datasets has the potential to reshape our ability to anticipate clinical and therapeutic outcomes. Credit: Kellie Holoski/Science Advances.