Skip to main content
. 2021 Jun 4;7(23):eabg1483. doi: 10.1126/sciadv.abg1483

Fig. 6. Hotspot map of CaSR missense mutations.

Fig. 6

(A to E) Missense mutations associated with five endocrine disorders—ADH1 (A), hypoparathyroidism (B), FHH1 (C), NSHPT (D), and hyperparathyroidism (E)—were mapped onto the ggCaSR-active structure. Each Ca atom of the mutated residues is represented by a sphere and colored red, magenta, blue, cyan, and green, respectively. ADH1 and hypoparathyroidism are caused by the gain-of-function CaSR mutations, while FHH1, NSHPT, and hyperparathyroidism are caused by the loss-of-function CaSR mutations.