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. 2021 Jun 4;7(23):eabf0614. doi: 10.1126/sciadv.abf0614

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 6 — (A) Full bioresorption process of the PDLLA drug coating with three stages: incubation, induction, and erosion and bioresorption. (B) Full bioresorption process of the nanoscale Zn sacrificial layer with three stages: PDLLA incubation stage, zinc biodegradation stage, and bioresorption of biodegradation products stage. (C) Full bioresorption process of the nitrided Fe platform with four stages: incubation of the PDLLA coating, incubation of the Zn sacrificial layer, biodegradation stage, and bioresorption of biodegradation products stage. The biodegradation stage of the nitrided Fe platform can be further divided into three substages in terms of the evolution of its degradation microenvironment: waterish PDLLA coating with or without partial protection by the zinc biodegradation products and direct contact with the vascular tissue. After complete biodegradation of the nitrided Fe platform, its biodegradation products gradually dissolve into the surrounding tissues and be engulfed by macrophages. (D) Tunable multistage biodegradation function of the scaffold realized via intercalation of the nanoscale Zn sacrificial layer with an adjustable thickness. (E) Comprehensive technical advantages of the PDLLA-Zn-nitrided Fe BRS.