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. Author manuscript; available in PMC: 2021 Jun 4.
Published in final edited form as: Curr Med Chem. 2020;27(25):4181–4193. doi: 10.2174/0929867326666191001125101

Fig. (4).

Fig. (4).

Aptamer-mediated anticoagulation during percutaneous coronary intervention and antidote-mediated control of factor IXa aptamer function. Utilizing Watson-Crick base-pairing rules, an antidote oligonucleotide (RB007) can be designed to interact with a portion of the factor IXa aptamer (RB006). Upon binding and unwinding the aptamer, the antidote converts the aptamer’s structure from a functional one to an inactive conformation thereby reversing the aptamer’s ability to inhibit factor IXa activity.