TABLE 3.
Severe DHTRs in patients receiving episodic RBC transfusions
| Hb (g/dL) |
||||||||
|---|---|---|---|---|---|---|---|---|
| Post-txn |
||||||||
| UPID | Clinical presentation | RBC indication | New antibody specificity | Pre-txn % Hb | % Hb (days post-RBCs) | Presentation (days post-RBCs) | Nadir Hb quant (%) (days post-RBCs) | DHTR management |
| 109 | HA, dizziness, lower back pain, jaundice | Pain (beginning trial of chronic RBCX) | Jkb | 9.4 7 U (RBCX) |
10.1 (0 days) 74% A (0 days) |
7.8 (+10 days) | 6.1 (+12 days) 62% A (+11 days) |
RBCs |
| 109 | Pain | Anemia due to DHTR (anti-Jkb) | C, hrB | 6.1 62% A |
8.5 (0 days) | 6.9 (+30 days) | 5.0 (+35 days) 6.5% A (+35 days) |
No records |
| 292 | Fatigue and dark urine | Chronic hypoxia, awaiting T+A | D | 6.5 | ND | 5.6 (+10 days) | 4.2 (+10 days) | IVIG, steroids |
| 292 | Dark urine | Preoperative for T+A | Jkb | 7.0 | ND | 6.7 (+6 days) | 4.5 (+6 days) | RBCs IVIG, steroids |
| 139 | BUE and BLE pain | Pain (beginning trial of chronic RBC exchange) | S | 10.9 6 U (RBCX) |
10.1 (0 days) 72.5% A (0 days) |
10.9 (+9 days) | 6.8 (+13 days) 20.6% A (+13 days) |
RBCs |
| 339 | Chest, BUE, BLE pain | Preoperative for hip surgery | S | 8.6 | 11.3 (+4 days) | 6.3 (+15 days) | 5.9 (+16 days) | Supportive |
| 244 | Chest pain and fever | Preoperative for cholecystectomy | Fya | 8.3 | 10.1 (0 days) | 6.5 (+23 days) | 4.5 (+25 days) | IVIG, steroids |
| 180 | BLE pain and fever | Acute chest syndrome | Jsa, Lea | 7.4 | 8.0 (0 days) | 7.2 (+11 days) | 4.8 (+15 days) | Supportive |
| 746 | Back, BUE, BLE pain | Preoperative for dental extraction | Wra, M | 7.7 | 10.8 (+1 day) | 5.7 (+20 days) | 3.6 (+22 days) | RBCs IVIG, steroids |
BLE = bilateral lower extremities; BUE = bilateral upper extremities; HA = headache; quant = quantification; RBCX = RBC exchange; T+A = tonsillectomy and adenoidectomy; txn = transfusion; U = units.