Figure 2.

OSER1‐AS1 expression is downregulated in non‐small cell lung cancer (NSCLC) tissues and associated with poor overall survival in The Cancer Genome Atlas Lung Adenocarcinoma (TCGA‐LUAD) patients. A, qRT‐PCR analysis of relative OSER1‐AS1 expression in NSCLC tissues compared with paired adjacent normal lung tissues. Left panel: all groups. Middle panel: smoker group. Right panel: non‐smoker group. The differential expression between tumor and adjacent normal lung tissue was compared using Wilcoxon matched pairs signed rank test: **P < .01; ***P < .001. B, Kaplan‐Meier curves for overall survival (OS) of TCGA‐LUAD patients expressing high and low expression levels of OSER1‐AS1. Left panel: overall group. Middle panel: smoker group. Right panel: non‐smoker group. Difference in survival between high‐ and low‐expression groups (divided by median OSER1‐AS1 expression value) was compared using the log‐rank test