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. 2021 May 2;112(6):2272–2286. doi: 10.1111/cas.14713

Figure 7.

Figure 7

Proposed model depicting the potential mechanisms of OSER1‐AS1 as a tumor suppressor ong non‐coding RNA (lncRNA) in non‐small cell lung cancer (NSCLC). Left panel: in a scenario of tumor progression, OSER1‐AS1 is suppressed by transcription factor MYC in the nucleus and inhibited by miR‐17‐5p in the cytoplasm. ELAVL1 are transported from the nucleus to the cytoplasm to stabilize mRNAs of MYC and increase its translational efficiency. The MYC proteins, in turn, downregulate OSER1‐AS1 and BCL2L11, and upregulate miR‐17‐5p. Right panel: in a scenario of tumor suppression, the cytoplasmic level of OSER1‐AS1 increases to a level to be able to overcome the inhibitory effect of miR‐17‐5p. Free cytoplasmic OSER1‐AS1 forms RBP‐RNA complexes with ELAVL1 to sequester it from its target MYC mRNAs and possibly other oncogenic genes regulated by ELAVL1