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. 2021 May 3;112(6):2335–2348. doi: 10.1111/cas.14921

FIGURE 6.

FIGURE 6

Adenovirus vector with shGAA has an oncolytic effect on pancreatic cancer (PC) tumors in vivo. (A) Tumor growth curves were plotted. The tumor growth was suppressed (P = .04) in the Adv‐shGAA group. (B) Kaplan‐Meyer curve of mice after AdV injection. Tumor‐rerated survival was prolonged (P = .034) in the Adv‐shGAA group. Median tumor diameter and tumor‐related survival were recorded twice a week. (C) GAA enzyme activity was suppressed in the Adv‐shGAA group. (D) The expression of GAA protein was suppressed, and cleaved caspase‐3 was overexpressed in the Adv‐shGAA group. (E) Body weight change during the experiment. There was no difference between Adv‐shScr and Adv‐shGAA groups. (F) Enucleated tumors were stained with H&E and anti–Ki‐67. The ratio of Ki‐67 positive cells (arrowheads) was reduced in the tumor of the Adv‐shGAA group. (G) TEM observed the defective mitochondria in the tumor of the Adv‐shGAA group. L, lysosome; M, mitochondria; N, nucleus. Scale bar: 50 nm