TABLE 3.
Histological findings of inflammatory changes in the MWCNT‐dosed group in the sequential necropsies test in Experiment 1
|
Wk‐8 (N = 7) a |
Wk‐16 (N = 11) |
Wk‐24 (N = 14) |
Wk‐32 (N = 13) |
|
|---|---|---|---|---|
| Infiltration of leukocyte | 2.3 ± 0.5 b | 1.9 ± 0.5 | 1.6 ± 0.8 | 1.0 ± 0.4 c |
| Edema | 2.4 ± 0.5 | 1.2 ± 0.8 | 1.5 ± 0.5 | 0.9 ± 0.5 c |
| Fibrosis | 1.9 ± 0.7 | 2.6 ± 0.5 | 1.7 ± 0.7 | 1.6 ± 0.9 c |
| Granulation | 2.1 ± 0.9 | 2.6 ± 0.5 | 1.9 ± 0.6 | 2.0 ± 0.6 |
| "Monocyte covering" | 1.9 ± 0.9 | 2.3 ± 0.8 | 2.1 ± 0.9 | 0.6 ± 0.7 c |
| Growth of connective tissue‐like cell | 0 | 0 | 0.6 ± 0.9 | 1.5 ± 0.9 d |
a
Effective number of rats.
b
Mean ± standard deviation of the severity score (see Materials and Methods) in each group.
c
Significant tendency of decrease from Wk‐8 to Wk‐32.
d
Significant tendency of increase from Wk‐8 to Wk‐32.