TABLE 4.
Individual histopathological data of all rats with mesothelioma in Experiment 1
| Grade | Animal number | Necropsy time (weeks after ip) | Type of necropsy | Histological type as an individual | Major subtype | Minor subtype | Vascular invasion, metastasis |
|---|---|---|---|---|---|---|---|
| Tumor Grade‐1 | #1‐32‐1 | 32 | ss | E | Escr | Sost | |
| #1‐32‐11 | 32 | ss | E | Escr | |||
| #1‐32‐12 | 32 | ss | E | Escr | |||
| #1‐32‐14 | 32 | ss | E | Escr | |||
| #2‐2 | 42 | ss | E | Escr | |||
| #2‐4 | 42 | ss | E | Escr | |||
| Tumor Grade‐2 | #1‐24‐3 | 24 | ss | E | Escr | ||
| #2‐11 | 25 | d | E | Erha | Escr | LN | |
| #1‐32‐6 | 32 | ss | E | Escr | |||
| #2‐5 | 42 | ss | E | Escr | Scon, B, Esol | LN | |
| Tumor Grade‐3 | #1‐32‐7 | 28 | ms | E | Escr | Scon | |
| #2‐8 | 41 | ms | S | Sost | Scon, B, Escr | LN | |
| #2‐1 | 42 | ss | S | Scon | Escr, Esol, B | ||
| Tumor Grade‐4 | #2‐3 | 35 | ms | S | Scon | B, Esol, Sdes, Esig | V, LN |
| #2‐10 | 37 | ms | S | Scon | B, Esol, Escr | LN | |
| #2‐6 | 39 | ms | S | Scon | Sple, Escr | ||
| #2‐12 | 39 | d | B | B | Erha, Scon, Esol, Escr | V, LN |
Abbreviations: B, biphasic; d, dead; E, epithelioid; Escr, epithelioid tumor showing "spherical connective tissue rich;" LN, metastasis in mediastinal lymph node; ms, moribund sacrifice. Other histological subtypes are shown by a rule described in Materials and Methods; S, sarcomatoid; ss, scheduled sacrifice; V, vascular invasion (tumor cells in capillary vessels of the lung parenchyma).