TABLE 2.

Assessment scale for the selection of NPC diagnostic biomarker candidates from 21 miRNAs

ID	Literature	FC ≥2 or FC ≤0.5	Expression>=50	P‐value	FDR	Log2 FC	Regulation
hsa‐miR‐134‐5p	3	1	0	1.652E‐03	0.208221	‐1.99721	Down
hsa‐miR‐205‐5p	3	1	1	4.531E‐03	0.333936	3.138441	Up
hsa‐miR‐409‐3p	2	1	1	4.370E‐05	0.023441	‐2.12066	Down
hsa‐miR‐484	2	1	1	6.206E‐03	0.359288	1.404613	Up
hsa‐miR‐486‐3p	2	0	1	2.905E‐02	0.621316	0.864261	Up
hsa‐miR‐486‐5p	2	1	1	4.456E‐03	0.333936	1.079406	Up
hsa‐miR‐92b‐3p	2	1	1	1.899E‐02	0.528252	1.117708	Up
hsa‐miR‐130b‐3p	2	1	0	1.471E‐02	0.473991	1.063487	Up
hsa‐miR‐195‐5p	2	0	1	8.500E‐03	0.359288	‐0.79029	Down
hsa‐miR‐320b	2	0	1	7.203E‐03	0.359288	0.756499	Up
hsa‐miR‐379‐5p	2	1	0	7.724E‐04	0.12457	‐1.85042	Down
hsa‐miR‐106b‐3p	1	0	1	2.039E‐03	0.230258	0.925956	Up
hsa‐miR‐204‐5p	1	1	1	2.709E‐03	0.272916	‐1.13235	Down
hsa‐miR‐3615	1	1	1	1.606E‐02	0.489985	1.000903	Up
hsa‐miR‐432‐5p	1	1	1	7.010E‐05	0.023441	‐2.11438	Down
hsa‐miR‐15b‐3p	0	1	1	9.265E‐03	0.360713	1.202865	Up
hsa‐miR‐185‐5p	0	1	1	5.165E‐03	0.333936	1.053123	Up
hsa‐miR‐320a‐3p	0	0	1	8.036E‐03	0.359288	0.746225	Up
hsa‐miR‐382‐5p	0	1	1	1.038E‐04	0.023441	‐1.73895	Down
hsa‐miR‐500a‐3p	0	1	1	5.216E‐03	0.333936	1.036111	Up
hsa‐miR‐501‐3p	0	1	0	3.143E‐03	0.272916	1.173655	Up

The literature score indicates the correlation between miRNAs and NPC that has been reported in previous studies. Score 0, no literature related to NPC found; score 1, only mentioned in literature on NPC; score 2, the upregulation or downregulation of miRNA was reported in NPC‐associated literatures; score 3, the role of the miRNA in NPC had been investigated.

Abbreviation: FC, fold change; FDR, false discovery rate.