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Mean plasma concentration‐time curves of milademetan. Top panel: day 1 of cycle 1; bottom panel: day 21 of cycle 1. Cohort 1: 60 mg 21/28 once daily (n = 3); cohort 2: 90 mg 21/28 once daily (n = 11 for day 1, n = 9 for day 21); cohort 3: 120 mg 21/28 once daily (n = 4 for day 1, n = 2 for day 21). Lower limit of quantification (0.500 ng/mL). Error bars represent standard deviation. QC, quaque die
