TABLE 2.

New identified KLF5 target genes in cancers

Types	Target genes	Functions	Cancers	References
Protein‐encoding genes	TNFAIP2	Promote cell migration and invasion	Breast cancer	27
	mPGES1	Promote the production of PGE2 and cell proliferation	Breast cancer	26
	Slug	Promote stemness	Breast cancer	7
	GDF15	Promote cell proliferation	Non–small‐cell lung cancer	40
	GSTM1	Increase oxidative stress by reducing glutathione	B‐cell acute lymphoblastic leukemia	35
	TNFRSF11a	Promote cell proliferation, migration, and invasion	Cervical cancer	39
	FYN	Promote cell migration	Bladder cancer	30
	Cyclin E1	Promote cell cycle	Bladder cancer	29
	AGGF1	Promote angiogenesis	Glioblastoma	31
	HNF4α	Promote cell proliferation	Gastric cancer	56
	MYC	Promote cell proliferation	Prostate cancer	32
	BECN1	Promote autophagy	Prostate cancer	38
	MKK7	Promote apoptosis induced by TNFα/TNFR1	Prostate cancer	36
	ALDH3A1	Promote cell proliferation and tumor growth	Esophageal squamous cell carcinoma	37
	PLA2G16	Promote glycolysis	Pancreatic cancer	34
	E2F1, Rad51	Promote cell proliferation	Pancreatic cancer	41
	ABCG2	Reduce the chemotherapy resistance to anthracyclines	Lung cancer	54
	IGF1	Inhibit the STAT3 signaling pathway and tumor metastasis	Prostate cancer	53
LncRNA	LINC00094	Promote cell proliferation	Esophageal squamous cell carcinoma	42
	NEAT1	Promote cell proliferation, and inhibit apoptosis	Gastric cancer	46
	LINC00346	Promotes cell growth, migration and invasion	Gastric cancer	45
	CASC15	Promotes cell proliferation, invasion, and tumor growth	Breast cancer	44
	RP1	Promote tumorigenesis	Breast cancer	43
	SNHG12	Promote invasion and metastasis	Colorectal cancer	47
miRNA	miR‐27a	Promote cell migration and invasion in response to cholesterol	Clear cell renal cell carcinoma	48
	miR‐200	Inhibit EMT	Epithelial cells	50
	miR‐145, miR‐124, miR‐183	Inhibit cell migration and invasion	Pituitary adenoma	51
	miR‐192	Inhibit EMT in the context of p53 loss or mutation	Liver cancer	49